MOLECULAR ANALYSIS OF STREPTOCOCCUS THERMOPHILUS SUPPORTING PROBIOTIC ACTION TOWARDS DRUG TARGETS

DSVGK KALADHAR, APPANA V S RAMAKRISHNA

Abstract


Streptococcus thermophilus is a Gram-positive facultative anaerobe with probiotic action. Nearly 2070 genes are
predicted in complete genome out of which 566 genes are related to hypothetical and uncharacterized genes. The
predicted gene percent obtained by characterization of complete genome of S.thermophilus is 72.67% with 25
functional categories. There is high number of transport, protein synthesis, binding and cell envelop proteins that
don’t have pathogen responses. The genes ptsK, glgP, malQ, lacZ, amyL, scrB, etc are related to energy metabolism
(with biodegradation and synthesis of polysaccharides) are found in chromosome CNRZ 1066. The genes such as
glgP, malQ, lacZ and amyl had shown direct interactions that has not found direct link with scrB gene. All the
proteins are observed with more the 50 percent identities that are present in homology models.


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