DEVELOPMENT AND EVALUATION OF FLOATING-MUCOADHESIVE DIPYRIDAMOLE TABLET

BIRAJDAR SHIVPRASAD M. DARVESHWAR JAGDEEP D

Abstract


The present study was aimed towards development and evaluation of tablet as a floating-Mucoadhesive drug delivery system, which can provide sustained release of the model drug. The work also was aimed to study various parameters affecting the behavior of floating-mucoadhesive tablet in oral dosage form. Formulation of Gastro-Retentive Dosage Forms (GRDFs) containing suitable drug candidate which would remain in stomach and/or upper part of GIT for prolonged period of time thereby is maximizing the drug release at desired site within the time before GRDFs leave the stomach and or upper part of GIT. Dipyridamole is BCS class II drug having low solubility and high permeability. It is soluble at low pH but insoluble in high pH (i.e. alkaline ph of small intestine )its oral bioavailability is 37-66% & biological half life is also short (40 min). In this study the bioavailability of the dipyridamole increase by using various concentration of HPMC, Carbapol and Sodium bicarbonate for swelling, mucoadhesive and floating behavior respectively. Bioadhesive strength depends upon carbapol as concentration of polymer increases bioadhesive strength also increases. HPMC is water Swealable but Carbapol is hydrogel in nature it restricts movement of polymer and affect the swelling index.

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