ANXIOLYTIC AND ANTIEPILEPTIC ACTIVITY OF AERIAL PARTS OF FLEMINGIA MACROPHYLLA IN RODENTS

CH. BHARGAVI, B. VENKATARAMANA

Abstract


The present study was undertaken to evaluate the anxiolytic and anti epileptic activity of ethonolic extract of Flemingia macrophylla by using different extract concentrations in rodents. Anxiolytic activity of FME was estimated by using Elevated plus maze test and light-dark model along with Mono Amino Oxidase enzyme levels in mice and the anticonvulsant activity of FME was estimated in rats by using MES , PTZ methods and those showing response were divided into four groups of six animals each. Group-I (Normal), Group-II (Diazepam 2mg/ Kg , p.o) , Group-III (FME 20mg/Kg in mice, 100mg/Kg in rats, p.o), Group-IV(FME 50mg/Kg in mice, 200mg/Kg , p.o). Animals treated with FME had shown a significant increase in enzyme levels and significant decrease in anxiety and onset of convulsions when compared with the diazepam treated animals. The ethanolic extract of Flemingia macrophylla afforded significant protection against anxiety and epilepsy. The activity may be due to the presense of flavonoids& glycosides.

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