IMMUNOMODULATORY ACTIVITY OF BALANITE ROXBURGHI

K. J.KORE, R.V.SHETE, M.P.KABRA, R.M.RACHHADIYA, A.R.ATTAL

Abstract


Besides having traditional use as an
immunomodulatory action, it is not well scientifically
establish. Hence present study was undertaken to screen
the immunomodulatory activity of ethanolic extract of
Balanite roxburghi leaves.Traditionally, leaves of Balanite
roxburghi are claimed to possess immunomodulatory
activity and hence the reason behind evaluating the
immunomodulatory activity of ethanolic extract of
Balanite roxburghi (EBR) leaves. The animals were
distributed into three groups consisting of six animals
each. The first group served as control, the second and
third group received low dose and high dose of ethanolic
extract of Balanite roxburghi (EBR) at 200 mg/kg, p.o.
and 400 mg/kg, p.o. respectively. The
immunomodulatory activity of EBR was evaluated in
Carbon clearance test, Effect on serum immunoglobulin,
Cyclophosphamide induced neutropenia. In all these
paradigms 400mg/kg dose of EBR was more effective
than its 200 mg/kg of dose. These results suggest that
Balanite roxburghi can be use as immunomodulator.


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