EFFECT OF BENZOIN RESIN ON THE SERUM BILIRUBIN LEVELS IN TEMPORARY JAUNDICE INDUCED BY PHENYLHYDRAZINE: A PRELIMINARY STUDY

RAJU.S, UMA MAHESHWARA RAO.V SREERAMULU REDDY.K, RAMYA.G, VASANTH KUMAR. G

Abstract


Bilirubin is the degradation product of heme, the
bulk of which is derived from hemoglobin of senescent
erythrocytes and hepatic hemoproteins. Bilirubin is
potentially toxic, but is normally rendered harmless by
binding to plasma albumin, and efficient hepatic clearance.
Jaundice, (also known as icterus) is a yellowish
pigmentation of the skin, the conjunctival membranes over
the sclerae (whites of the eyes), and other mucous
membranes caused by hyperbilirubinemia (increased levels
of bilirubin in the blood). Complications of jaundice
include sepsis especially cholangitis, biliary cirrhosis,
pancreatitis, coagulopathy, renal and liver failure.
Treatment of rats with Phenylhydrazine 5 mg/ kg body
weight for five days resulted in the development of
jaundice as BR level was found to be higher than 2 mg/dL.
Bilirubin lowering potential of Benzoin ethyl alcohol
extract was evaluated in temporarily jaundiced adult
wistar rats. Treatment of these rats with Benzoin extract
for seven days reduced the BR level significantly to the
normal value. Whereas smaller dose (10mg/kg body
weight) resulted in the reduction in BR level from 2.51 ±
0.02 to 0.90 ± 0.01 mg/dL, higher doses of 20 and 40
mg/kg body weight were found to be more effective in
reducing the bilirubin level from 2.54 ± 0.01 to 0.82 ±
0.01 mg/dL and from 2.49±0.02 to 0.66±0.01 mg/dL,
respectively. Therefore, Benzoin ethyl alcohol extract can
be used to reduce bilirubin concentration to a normal level
in jaundiced subjects.


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