EFFECT OF EVOLVULUS ALSINOIDES EXTRACT ON MEMBRANE BOUND ENZYME ACTIVITIES IN THE TISSUES OF STREPTOZOTOCIN INDUCED DIABETIC RATS

DURAISAMY GOMATHI, GANESAN RAVIKUMAR, MANOKARAN KALAISELVI, KANAKASABAPATHI DEVAKI,CHANDRASEKAR UMA

Abstract


The present study investigated the possible therapeutic effects of the whole plant ethanolic extract of Evolvulus alsinoides
on oral glucose tolerance test and the membrane bound enzyme activity in streptozotocin induced diabetes rats. The
antidiabetic effect of ethanolic extract of Evolvulus alsinodes were studied at different concentrations like 50 mg, 150 mg and
300 mg/kg body weight in streptozotocin induced diabetic rats for 14 days. In that 150 mg/kg dosage showed significant
reduction in blood glucose. Hence further studies were carried out by using the dosage of 150 mg/kg. The effects of an ethanol
extract of Evolvulus alsinoides on the activities of marker enzymes were also examined in the liver and kidney tissues.
Decreased levels of Sodium potassium, magnesium ATPases were observed in streptozotocin induced diabetic rats whereas
calcium ATPase was increased in diabetic rats. Administration of plant extract to diabetic rats for 45 days restored all membrane
bound enzyme activities as to that of control rats and there is no significant difference were found between control and plant
extract alone groups. It might be related in part to the modification of fatty acid content during diabetes. Thus the ethanolic
extract of Evolvulus alsinoides may alleviate liver and renal damage associated with streptozotocin induced diabetes
mellitus in rats.


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