ISOLATED PERIORBITAL EDEMA ASSOCIATED WITH NAPROXEN: A CASE REPORT
Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs), resulting in urticaria and angioedema, is being observed
with increasing frequency partly due to the large size of the exposed (at risk) population. Prevalence rates range from 0.1–
0.3%. Facial angioedema constitutes the most common form of clinical presentation, and one-third of the patients show a
mixed clinical pattern of cutaneous (urticaria and/or angioedema) and respiratory symptoms which include upper respiratory
tract edema, rhinorrhea, cough, breathlessness and tearing. But to the best of our knowledge there is no isolated periorbital
edema reported to date due to naproxen in the literature. In this report, a 62-year-old woman who developed reversible
bilateral periorbital edema after naproxen ingestion was presented. The periorbital edema due to NSAIDs was discussed.
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controlled drug challenges in 98 patients. J Allergy Clin Immunol. 1996;98:678-685.
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Quiralte J, Blanco C, Castillo R, et al. Intolerance to nonsteroidal anti-inflammatory drugs: results of controlled drug
challenges in 98 patients. J Allergy Clin Immunol. 1996;98:678-685.
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