IN VITRO FREE RADICAL SCAVENGING ACTIVITY AND SECONDARY METABOLITES IN PASSIFLORA FOETIDA L.
Investigation of the total phenol content, total flavanoid content, in vitro lipid peroxidation and radical scavenging activities from
Passiflora foetida L. Extraction from various solvents were used for the estimations. Among the five extracts, the flavanoid and
phenol content was found to be high in aqueous and ethanol extract of leaf when compared to root extract. Different
concentrations of plant extracts were used (100 – 500 μg/ml) and results showed strong reducing power at the concentration of
500μg/ml and the activity increases in dose dependent manner as to that of standard BHT. That the highest free radical
scavenging activity was found in ethanolic extract of leaf of Passiflora foetida L. Consumption of P. foetida L. will reduce the
free radical formation and afford protection against reactive oxygen species produced during diabetes which may be due to the
presence of phenol and flavanoids.
Aseervatham J, Palanivelu S, Panchanadham S. Semecarpus anacardium (Bhallataka) alters the glucose metabolism and energy production in diabetic rats. Evidence-based complementary and alternative medicine 2011; 10(4):1-9.
Lai H, Singh NP. Oral artemisinin prevents and delays the development of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat. Cancer Lett 2006; 231(1):43-48.
Sun J, Chu, YF, Wu XZ, Liu RH. Antioxidant and anti-proliferative activities of fruits. Journal of Agricultural and Food Chemistry 2002; 50 (25):7449-7454.
Kalia K, Flora SJ. Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. J. Occup. Health 2005; 47 (1):1–21.
Archana, Jatawa S, Paul R, Tiwari A. Indian Medicinal Plants: A rich source of natural immuno modulator. International Journal of Pharmacology 2011; 7 (2): 198-205.
Sasikala V, Saravana S, Parimelazhagan T. Evaluation of antioxidant potential of different parts of wild edible plant Passiflora foetida L. Journal of Applied Pharmaceutical Science 2011;1(04):89-96.
Narayan DP, Purohit SS, Arun K, Sharma, Tarun Kumar A. Hand book of Medicinal plants 2003; 383.
Sathish R, Sahu A, Natarajan K. Antiulcer and antioxidant activity of ethanolic extract of Passiflora foetida L. Indian J Pharmacol 2011; 43(3):336–339.
Ordon LE, Gomez JD, Vattuone MA, Isla MI. Antioxidant activities of Sechium edule (Jacq.) Swartextracts. Food Chem 2006; 97: 452-8
Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolbdic phosphor tugnstic acid reagents. Am J Enol Vitic 1965; 16: 144-58.
Oyaizu M. Studies on products of browning reaction prepared from glucosamine. Japanese Journal of Nutrition 1986; 44: 307–15.
Blois MS. Antioxidant determinations by the use of stable free radical. Nature1958; 81: 1199-2000.
Okhawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry1979; 95: 351-358.
Kessler M, Ubeaud G, Jung L. Anti and pro-oxidant activity of rutin and quercetin derivatives. Journal of Pharmacy and Pharmacology2003; 55:131- 142.
Choi CW, Kim SC, Hwang SS, Choi BK, Ahn HJ. Antioxidant activity and free radical scavenging capacity between Korean medicinal plants and flavonoids by assay-guided comparison. Plant Science 2002; 163:1161-1168.
Vijayakumar S, Presannakumar G, Vijayalakshmi NR. Antioxidant activity of banana flavonoids. Fitoterapia 2008; 79: 279-282.
Middleton JE, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells, implications for inflammation, heart disease and cancer. Pharmacological Reviews 2000; 52:673-751.
Dorman HJD, Kosar M, Kahlos K, Holm Y, Hilturien R. Antioxidant properties and composition of aqueous extract from Mentha species, hybrid varieties and cultivars. J Agric Food Chem 2003; 51:4563-4569.
Chung YC, Chen SJ, Hsu CK, Chang CT, Chou ST. Studies on the antioxidative activity of Graptopetalum paraguayense E. Walther. Food chem 2005; 91:419-424.
Ahn R, Kumazawa S, Usui Y, Nakamura J, Matsuka ZF, Nakayama T. Antioxidant activity and constituent of propolis collected in various areas of China. Food Chem 2007; 101: 1383-1392.
Devaki K, Beulah U, Akila G, Sunitha M, Narmadha R, Gopalakrishnan VK. Effect of aqueous leaf extract of B. tomentosa on GTT of normal and diabetic rats. Pharmacologyonline 2011; 3:195-202.
Rasool SN, Jaheerunnisa S, Jayaveera KN, Suresh Kumar C. In vitro callus induction and in vivo antioxidant activity of Passiflora foetida L. leaves. International Journal of Applied Research in Natural Products 2011; 4 (1):1-10.
Ragavendran P, Sophia D, Arulraj C, Gopalakrishnan VK. Cardioprotective effect of aqueous, ethanol and aqueous ethanol extract of Aerva lanata (Linn.) against doxorubicin induced cardiomyopathy in rats. Asian Pacific Journal of Tropical Biomedicine 2012; 1-7.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.
Listed as Green Publisher
Powered by Informatics India Ltd