FORMULATION AND EVALUATION OF TOPICAL DICLOFENAC SODIUM GEL USING DIFFERENT GELLING AGENT

Y. S. TANWAR, AMIT KUMAR JAIN

Abstract


The present research has been undertaken with the aim to develop a topical gel formulation of Diclofenac sodium using
different gelling agent carbopol, Na CMC, HPMC (K4M) and sodium alginate in different concentration, which would
attenuate the gastrointestinal relater toxicities associated with oral administration. They were evaluated for physicochemical
properties such as homogeneity, grittiness, viscosity, pH, Spreadability, drug content, skin irritancy, in vitro drug release,
stability studies. The in vitro drug release rate of gel was evaluated using Franz diffusion cell containing cellophane
membrane with phosphate buffer pH 6.8 as the receptor medium. Studies showed that drug release was decrease with
increase in gelling agent concentration because polymer concentration increases, viscosity increases. Drug was absorbed
from site of application as long as it remains in higher concentration gelling agent in solution form.
Keywords: Diclofenac Sodium, carbopol, hydroxyl propyl methyl cellulose, sodium alginate anti‐inflammatory activity.


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