FORMULATION AND PROCESS OPTIMIZATION OF GASTRO-RETENTIVE FLOATING TABLET OF ONDANSETRON HCL

MEHTA KALPESH K, PATEL NAVNIT K, GANATRA MAULIK H, PATEL TUSHAR D, PATEL N.J

Abstract


Ondansetron HCl is a potent, highly selective 5-HT3
receptor-antagonist used to prevent nausea and
vomiting, mainly in patients undergoing chemotherapy
and radiation treatments. The aim of present work was
to formulate, evaluate and optimize gastro-retentive
tablet of Ondansetron HCl which would be
advantageous, that can provide prolong gastric
retention and increase efficacy of the dosage form. In
formulation optimization, different formulation of
HPMC polymer, NaCMC and NaHCO3 were studied
with help of 32 full factorial designs. It was found that
HPMC K4M with concentration 40%, NaCMC 5%
and NaHCO3 with 17% concentrations showed good
sustained and floating ability and it releases 94.51%
drug within 24 hrs. During study of effect of process
parameters, it was concluded that release of drug
decreases with decreasing granular size. The drying
time (10 and 20 min) and drying temperature (40° and
50°C), does not have any significant effect on the
release profile of drug.


Keywords


Ondansetron HCL, gastro retentive, 5-HT3 receptorantagonist, 32 full factorial design, HPMC(Hydroxy Propyl Methyl Cellulose) K4M, NaCMC (Na Carboxy Methyl Cellulose), NaHCO3

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