APPROACHES AND DEVICES USED IN PULMONARY DRUG DELIVERY SYSTEM: A REVIEW
Targeting drug delivery into the lungs has become one of the most important aspects of systemic or local drug delivery.
Consequently, in the last few years, techniques and new drug delivery devices intended to deliver drugs into the lungs have
been widely developed. Currently, the main drug targeting regimens include direct application of a drug into the lungs,
mostly by inhalation therapy using either pressurized metered dose inhalers (pMDI) or dry powder inhalers (DPI).
Intratracheal administration is commonly used as a first approach in lung drug delivery in vivo. To convey a sufficient dose
of drug to the lungs, suitable drug carriers are required. These can be solid, liquid, or gaseous excipients. Liposomes, nano
and microparticles, cyclodextrins, microemulsions, micelles, suspensions, or solutions are all examples of this type of
pharmaceutical carrier that have been successfully used to target drugs into lungs. The use of micro reservoir type systems
offers clear advantages, such as high loading capacity and possibility of controlling size and permeability, and thus of
controlling the release kinetics of the drugs from the carrier systems. These systems make it possible to use relatively small
numbers of vector molecules to deliver substantial amounts of a drug to the target. This review discusses the approaches and
devices required to be administer drug into the lungs.
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