RELATIONSHIP BETWEEN HYPOMAGNESEMIA AND DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS

R. DEEPTI1, G. NALINI, ANBAZHAGAN

Abstract


Magnesium is an important macro mineral in the mammalian cells. It is a cofactor for many enzymes involved in
lipid metabolism like lipoprotein lipase, pyrophosphatase etc. In magnesium deficiency, these enzymes are defective and leads to
dyslipidemia in type 2 diabetic patients. Objective: To observe the association between hypomagnesemia and dyslipidemia in
type 2 diabetic patients. Methodology: A case control South Indian population study consisted of control group (40 healthy
individuals) and case group (203 patients who were diagnosed as type 2 diabetes). Serum magnesium and lipid profile was
analyzed in blood samples using standard kits in fully automated analyzer. The data was analyzed using Student’s ‘t’ test and
correlation coefficient. Result: In the present study, a significant low serum magnesium levels (p<0.01) in case group was
observed when compared to control group. A significant decreased cholesterol levels (p<0.05) and serum HDL levels (p<0.001)
was observed in case group when compared to control group. In case group, we found a significant increased triglycerides
(p<0.05) and LDL levels (p<0.001) when compared to control group. A positive correlation was observed between magnesium
and cholesterol (r = 0.195, p<0.01), magnesium and LDL (r = 0.202, p<0.01), magnesium and total cholesterol HDL ratio (r =
0.142, p<0.05) in the case group. Conclusion: We observed hypomagnesemia in type 2 diabetes patients with dyslipidemi


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