QUANTITATIVE DETERMINATION OF TENOFOVIRDISPROXIL FUMARATE AS AN ACTIVE PHARMACEUITCAL INGRADIENT IN TABLET FORMULATIONS BY VISIBLE SPECTROPHOTOMETRY
In the present investigation, a direct, simple and sensitive visible spectrophotometric method without using any
buffer solution is described for the assay of tenofovir disproxil fumarate in pure and tablet dosage forms. The
method is based on the formation of yellowish brown colored species by the drug with NQS reagent and exhibits
absorption maxima at 451 nm. Regression analysis of Beer-Lambert plots showed good correlation in the
concentration ranges (8-40) μg/ml. The proposed method is applied to commercial available tablets and the results
are statistically compared with those obtained by the reported UV reference method and validated by recovery
studies. The results are found satisfactory and reproducible. The method is applied successfully for the estimation of
the tenofovir disproxil fumarate in the presence of other ingredients that are usually present in dosage forms. The
method offers the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to
resource-poor settings without the need for expensive instrumentation and reagents.
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