Evaluating Endometrial Thickness and Vascular Ultrasound Pattern and Pregnancy Outcomes in Intrauterine Insemination Cycle

Mojgan Javedani Masrour, Atena Shafaie Ladan Yoonesi, Hossein Aerabsheibani, Sanaz Javedani Masrour

Abstract


The current study aims to investigate whether endometrial thickness and pattern, and blood flow in color Doppler of sonography on the day of administration is a predictor of intrauterine insemination (IUI) success. The study was designed as a cross-sectional prospective clinical study with one-hundred women undergoing an IUI cycle. Interventions of the study include endometrial thickness and pattern and color Doppler flow on the day of administration and cycle parameters were compared between pregnant and non-pregnant patients. Main outcome measures are endometrial thickness and patterns and blood flow in color Doppler. The results showed that the overall pregnancy rate was 38%, which mean that endometrial blood flow on the day of administration was significantly greater in cycles, pregnancy achieved, but endometrial thickness and pattern of sonography were found to have no predictive value on endometrial receptivity. In multi-variant analysis, the following variable affected the pregnancy rate: the women’s age, duration of infertility, type, number of IUI cycle, the number of ampules to stimulate dominant follicle, sperm count. In our study, this variability was found to have no predictive value on the outcome of IUI but endometrial flow in color Doppler was positively associated pregnancy outcome.


Keywords


Endometrial Thickness, Polycyctic Ovarian Syndrome, Vascular Ultrasound Insemination Cycle

Full Text:

PDF

References


Berek JS, Novak E. Berek and Novak’s Gynecology. Philadelphia,

USA: Lippincott Williams and Wilkins; 2007.

Esmailzadeh S, Faramarzi M. Endometrial thickness and

pregnancy outcome after intrauterine insemination. Fertility

and Sterility. 2007 [cited 2007 Apr 17];88(2):432–7.

Yilmaz N, Kiliç S. Endometrial parameters in IVF and

IUI administration on elderly women. Turk J Med Sci.

;40(30):343–48.

Habibzadeh V, Mahani SNN, Kamyab H. The correlation of

factors affecting the endometrial thickness with pregnancy

outcome in the IUI cycles. Iranian Journal of Reproductive

Medicine. 2011 [cited 2011 Jan 1];9(1):41–6.

Kim A, Han JE, Yoon TK, Lyu SW, Seok HH, Won HJ. Relationship

between endometrial and subendometrial blood

flow measured by three-dimensional power Doppler ultrasound

and pregnancy after intrauterine insemination. Fertility

and Sterility. 2010 [cited 2009 May 26];94(2):747–52.

Wang L, Qiao J, Li R, Zhen X, Liu Z. Role of endometrial

blood flow assessment with color Doppler energy in predicting

pregnancy outcome of IVF-ET cycles. Reproductive

Biology and Endocrinology. 2010 [cited 2010 Oct 20];8:122.

Aghahoseini M, Tuba K, Marsousi V, Aleyasin A. Assessment

of endometrial-subendometrial blood flow detected

by color doppler sonography and uterine receptivity in infertile

women. Acta Medica Iranica. 2008;46(6):461–6.

Riad ON, Hak AA. Assessment of endometrial receptivity

using Doppler ultrasonography in infertile women undergoing

intrauterine insemination. Gynecological Endocrinology.

;30(1):70–3.

Yaman C, Ebner T, Sommergruber M, Polz W, Tews G. Role

of three-dimensional ultrasonographic measurement of

endometrium volume as a predictor of pregnancy outcome

in an IVF-ET program: a preliminary study. Fertility and

Sterility. 2000 [cited 2000 Oct 6];74(4):797–801.

Tsai HD, Chang CC, Hsieh YY, Lee CC, Lo HY. Artificial

insemination. Role of endometrial thickness and pattern,

of vascular impedance of the spiral and uterine arteries, and

of the dominant follicle. The Journal of Reproductive Medicine.

[cited 2000 Apr 11];45(3):195–200.

Kovacs P, Matyas S, Boda K, Kaali SG. The effect of endometrial

thickness on IVF/ICSI outcome. Hum Reprod.

[cited 2003 Oct 31];18(11):2337–41.

Rieger L, Honig A, Sutterlin M, Kapp M, Dietl J, Ruck P, et

al. Antigen-presenting cells in human endometrium during

the menstrual cycle compared to early pregnancy. Journal

of the Society for Gynecologic Investigation. 2004 [cited

Oct 2];11(7):488–93.

Kolibianakis EM, Zikopoulos KA, Fatemi HM, Osmanagaoglu

K, Evenpoel J, Van Steirteghem A, et al. Endometrial

thickness cannot predict ongoing pregnancy achievement

in cycles stimulated with clomiphene citrate for intrauterine

insemination. Reproductive Biomedicine Online. 2004

[cited 2004 Feb 5];8(1):115–8.

Vlaisavljevic V, Reljic M, Gavric-Lovrec V, Kovacic B. Subendometrial

contractility is not predictive for in vitro fertilization

(IVF) outcome. Ultrasound in Obstetrics andGynecology.

[cited 2001 Apr 20];17(3):239–44.

Yaman C, Ebner T, Jesacher K, Sommergruber M, Radner

G, Tews G. Sonographic measurement of endometrium

thickness as a predictive value for pregnancy through IVF.

Ultraschall Med. 2002 [cited 2002 Sep 13];23(4):256–9.

Weissman A, Gotlieb L, Casper RF. The detrimental effect

of increased endometrial thickness on implantation

and pregnancy rates and outcome in an in vitro fertilization

program. Fertility and Sterility. 1999 [cited 1999 Feb

;71(1):147–9.

Dietterich C, Check JH, Choe JK, Nazari A, Lurie D. Increased

endometrial thickness on the day of human chorionic

gonadotropin injection does not adversely affect

pregnancy or implantation rates following in vitro fertilization-

embryo transfer. Fertility and Sterility. 2002 [cited

Apr 9];77(4):781–6.

Reuter KL, Cohen S, Furey L, Baker S. Sonographic appearance

of the endometrium and ovaries during cycles

stimulated with human menopausal gonadotropin. The

Journal of Reproductive Medicine. 1996 [cited 1996 Jul

;41(7):509–14.

Tomlinson MJ, Amissah-Arthur JB, Thompson KA, Kasraie

JL, Bentick B. Prognostic indicators for intrauterine insemination

(IUI): statistical model for IUI success. Hum Reprod.

[cited 1996 Sep 1];11(9):1892–6.

Hock DL, Bohrer MK, Ananth CV, Kemmann E. Sonographic

assessment of endometrial pattern and thickness

in patients treated with clomiphene citrate, human menopausal

gonadotropins, and intrauterine insemination. Fertility

and Sterility. 1997 [cited 1997 Aug 1];68(2):242–5.

Kamath MS, Bhave P, Aleyamma T, Nair R, Chandy A,

Mangalaraj AM, et al. Predictive factors for pregnancy after

intrauterine insemination: A prospective study of factors

affecting outcome. Journal of Human Reproductive Sciences.

[cited 2011 Jan 15];3(3):129–34.

Ghosh C, Buck G, Priore R, Wacktawski-Wende J, Severino M. Follicular response and pregnancy among infertile

women undergoing ovulation induction and intrauterine

insemination. Fertility and Sterility. 2003 [cited 2003 Aug

;80(2):328–35.

Iberico G, Vioque J, Ariza N, Lozano JM, Roca M, Llacer J,

et al. Analysis of factors influencing pregnancy rates in homologous

intrauterine insemination. Fertility and Sterility.

[cited 2004 May 12];81(5):1308–13.

De Geyter C, Schmitter M, De Geyter M, Nieschlag E,

Holzgreve W, Schneider HP. Prospective evaluation of the

ultrasound appearance of the endometrium in a cohort of

,186 infertile women. Fertility and Sterility. 2000 [cited

Jan 13];73(1):106–13.

Abedi G, Darvari S H, Nadighara A, Rostami F. The relationship

between quality of life and marriage satisfaction

in infertile couples using path analysis. J Mazandaran Univ

Med Sci. 2014; 24(117):184–93.

Abedi Gh, Azimehr L, Rostami F. Mohammadi, S. Applying

a model of patient’s right in the state hospital, Sari, Iran.

International Journal of Collaborative Research on Internal

Medicine and Public Health. 2012 Feb;4(2):103–10.


Refbacks

  • There are currently no refbacks.




 

 

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

 

Listed as Green Publisher

Powered by Informatics India Ltd