DEVELOPMENT OF ROPINIROLE (FREE BASE) TRANSDERMAL PATCH US ING BLENDS OF HYDROXYPROPYL METHYLCELLULOSE/EUDRAGITS AND IT’ S IN VITRO/ IN VIVO CHARACTERIZATION

SRAVANTHI A, SANTHOSH KUMAR M PRAVEEN KUMAR G, JITHAN A

Abstract


The objective of this study was to
prepare and evaluate a matrix type transdermal patch of
ropinirole using blends of
hydroxypropylmethylcellulose (HPMC) and Eudragit
RL 100 and HPMC and Eudragit ERS100. Materials
and Methods: Ropinirole free based used as the drug
entity was prepared from its hydrochloride salt.
Suitability of the polymers in the form of drug-excipient
compatability was determined prior to formulation
development using FTIR. Patches were developed using
solvent evaporation technique. Limonene was used as
a penetration enhancer. Moisture absorption,
moisture content and mechanical properties, drug
content, in vitro drug release, drug-excipient compatibility,
in vitro skin permeation were the in vitro parameters
measured. Short-term stability, skin irritation and
in vivo drug release were measured with one
optimized formulation. Results and discussion:
Ropinirole free base was used successfully in the
preparation of the patches. FTIR studies indicated no
interaction between the drug and the polymers of this
study. Formulations developed were strong and not
brittle with uniform drug release. Patches containing
higher HPMC generally showed higher drug release
and permeation. Drug release and permeation decreased
with increase in the concentrations of Eudragits. Drug
release studies indicated Higuchi model for all the
patches with a diffusion mechanism of non-fickian type.
Short-term stability studies indicated that ropinirole
was stable in the patches. Patches did not cause any skin
irritation. In vivo the optimized patch sustained drug
release for 24 hours upon one time administration.
Conclusion: Clinically viable ropinirole transdermal
patch can be successfully prepared from its base form
using HPMC/Eudragits.


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