DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND TAPENTADOL HYDROCHLORIDE IN TABLET DOSAGE FORM

SAMIL D. DESAI*, BHAVNA A. PATEL, SHRADDHA J. PARMAR, NAITIK N. CHAMPANERI

Abstract


A simple, precise, accurate and reproducible spectrophotometric method has been developed for
Simultaneous estimation of Paracetamol and Tapentadol Hydrochloride by employing first order derivative
zero crossing method in 0.1 N Sodium Hydroxide. The first order derivative absorption at 257.1 nm (zero
cross point of Paracetamol) was used for quantification of Tapentadol HCl and 289.0 nm (zero cross point of
Tapentadol HCl) for quantification of Paracetamol. The linearity was established over the concentration
range of 15-35


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