ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITY OF JATROPHA CURCAS LINN.

J.SANGEETHA, K. DIVYA, MV PRASHANTH A VAMSIKRISHNA, G LEELA RANI

Abstract


Jatropha curcas Linn., a Bio-diesel plant known for various medicinal uses in folklore has been evaluated for few pharmacological aspects. The plant is being collected, dried and extracted by maceration method with ethanol and water. They were concentrated using vacuum distillation and the extracts were used for the evaluation of anti-inflammatory, analgesic and antibacterial activity using Formalin induced paw edema method, eddy’s hot plate method and disc diffusion method respectively. The analgesic and anti-inflammatory activity of bark water extract and leaf water extract was found significant at P<0.05 and P<0.001 respectively. The maximum analgesic effect was observed at 60min at 300mg/kg (i.p) and was similar to that of standard aspirin (50mg/kg). The edema inhibition effect was 100% for leaf water extract (300mg/kg) after 24hrs and was found effective when compared with standard Ibuprofen (50mg/kg). The antibacterial activity was also found effective at 10mg/ml.

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