REVERSE PHASE HPLC METHOD FOR THE ANALYSIS OF NEBIVOLOL IN PHARMACEUTICAL DOSAGE FORMS

B.S.SASTRY, D.SRINIVASULU H.RAMANA

Abstract


Nebivolol1chemically [1-(6-fluorochroman-2-yl)-{[2-(6-fluorochroman-2-yl)-2-hydroxyethyl]
amino} ethanol)] is a long acting cardio selective beta-blocker currently used for the
treatment of hypertension. A sensitive and precise RP-HPLC method has been developed and
validated for the determination of Nebivolol in dosage forms. The drug was chromatographed on
a C-18 column using a mixture of water and Methanol in the ratio (40:60) as mobile phase at a
flow rate of 1.0 ml/min. Chlorzoxazone was used as an internal standard and detection was done
at 282 nm. Linearity range is found to be 5-100 μg/ml with a correlation coefficient 0.9999 .The
mean recoveries obtained for Nebivolol range from 99.6-100.8%. Due to its simplicity,
rapidness, high precision and accuracy the proposed method may be used for determining
Nebivolol in bulk and dosage forms.


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