SCREENING OF SYNTHETIC NEW HETEROCYCLIC DERIVATIVES OF 3- FORMYL-4-HYDROXYCOUMARIN FOR ANTI-INFLAMMATORY ACTIVITY IN ALBINO RATS

Abstract

Coumarins have multiple biological activities; various coumarin-related derivatives are
recognized as inhibitors of the lipoxygenase and cycloxygenase pathways of arachidonate
metabolism. Several natural or synthetic coumarins with various hydroxyl and other substitutes
were found to inhibit lipid peroxidation and to scavenge hydroxyl radical and superoxide anion
and to influence processes involving free radical mediated injury. The heterocyclic derivatives of
3-formyl-4-hydoxycoumarin were found to present significant anti-inflammatory effect, the
compounds inhibited formalin induced hind paw edema and they also significantly suppressed
the formation of granuloma tissue in cotton pellet induced chronic model of inflammation. The
result showed that the anti-inflammatory (both acute & chronic) effect of the test compound Ib is
comparable to that of standard Antiinflammatory drug Diclofenac Sodium.