ANTIFILARIAL ACTIVITY OF PLUMERIA ALBA LINN BARK

WASEEM RIZVI, ANIL KUMAR ,RAKESH KUMAR, NAKHAT HAIDER

Abstract


The aqueous extract of Bark of Plumeria. alba was tested for its effect on the
spontaneous movements of the whole worm (w.w) preparation and nerve muscle (n.m)
complex of Setaria cervi a cattle filarial parasite, and on the survival of microfilariae .
The aqueous extract could inhibit the spontaneous movements of S.cervi, characterized
by initial stimulation followed by reversible paralysis. The concentration required to
produce similar effect on nerve muscle complex was less as compared to the whole
worm. The lethal concentration 50 (LC50) and lethal concentration 90 (LC90) for aqueous
extract were 80 ng/ml and 105 ng/ml respectively.


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