STEREOSELECTIVE ENZYMATIC SYNTHESES OF ANGIOTENSIN CONVERTING ENZYME INHIBITOR DRUGS

V .V. S. V. PRASAD,P.RAMA RAO, ,A. NAIDU, P. VENKATESWAR RAO

Abstract


Angiotensin converting enzyme (ACE) inhibitor drug intermediates, ECPPA
(S)-ethoxycarbonyl-3-phenylpropyl) L-alanine) ,ECPPL(N2-(1(S) ethoxycarbonyl-3
Phenyl propyl)- N6 trifloro acetyl L-lysine)have been synthesized by using the
enzyme Lipase. Angiotensin converting enzyme inhibitor drug intermediates are
synthesized stereo selectively by using Novo SP 435 supplied by Novozymes. Choral
specificity for the ACE inhibitor drug intermediates is (SS). The formed desired (SS)
isomer is matched by the standard sample with HPLC method.


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