SPAN-60 NIOSOMAL ORAL SUSPENSION OF FLUCONAZOLE: FORMULATION AND IN VITRO EVALUATION

SANDEEP K S,MEENAKSHI C, NARAYANAPILLAY A

Abstract


Niosomes have shown promise as cheap and chemically stable drug delivery
systems. Niosomes have been prepared with different molar ratios of surfactant and
cholesterol and their morphological properties have been determined by scanning
electron microscopy. Different batches of Fluconazole niosomal preparations were
prepared by changing the surfactant concentration but keeping the cholesterol
concentration constant. The surfactant used was Span 60 and the five batches of
niosomal preparations prepared were in the ratios 1:1:1, 1.5:1:1, 2:1:1, 2.5:1:1 and
3:1:1 (surfactant: cholesterol: drug). Furthermore, the release profile, entrapment
efficiency, size distribution and stability of these niosomes under various
temperatures were studied.


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