QUANTITATIVE ESTIMATION OF NEVIRAPINE BY HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY
A simple, accurate and precise HPTLC method has been developed and validated for the
estimation of nevirapine from bulk drug and tablet formulations. The separation was achieved on
TLC plates using appropriate solvent system. The spots so developed were densometrically
scanned at 283 nm. The linearity of the method was found to be within the concentration range
of 2.50μg/ml to 62.50μg/ml. The validation parameters, tested in accordance with the
requirements of ICH guidelines, prove the suitability of this method. The method was
successfully applied for determination of drug in tablets, wherein no interference from tablet
excipients was observed, indicating the specificity of the developed method. Thus the proposed
method can be used successfully for routine analysis of nevirapine from capsule and tablet
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