ANXIOLYTIC AND ANTICONVULSANT ACTIVITY OF ALCOHOLIC EXTRACT OF HEART WOOD OF CEDRUS DEODARA ROXB IN RODENTS

GL VISWANATHA,K NANDAKUMAR, SHYLAJA H

Abstract


The present study was undertaken to evaluate the anxiolytic and anti-convulsant activity
of the alcoholic extract of heart wood of Cedrus deodara (ALCD). 50,100 and 200 mg/kg of
alcoholic extract of Cedrus deodara (ALCD) were tested for its anxiolytic and anticonvulsant
activity. Elevated plus maze model (EPM), Actophotometre, Light-dark model were used for
testing anxiolytic activity and Pentylene tetrazole (PTZ) induced convulsions and Maximal
electro shock (MES) induced convulsions models in mice were used for the assessment of its
anticonvulsant activity, Pretreatment with ALCD and estimation of GABA in rat brain tissues
also performed to study the effect of ALCD (30, 100 mg/kg) on GABA levels of brain. In
Actophotometre test, higher doses (100 and 200mg/kg) of ALCD has showed significant CNS
depression by reducing locomotor activity in mice. In EPM the 100 and 200mg/kg of ALCD
has increased the time spent in the open arm and decreased time spent in the closed arm. In
Light-dark model the 100 and 200mg/kg of ALCD has showed significant increase in the time
spent in light zone when compare to the dark zone. In PTZ induced convulsions model 100 and
200 mg/kg of ALCD has increased the onset of clonus and tonic seizures.


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