PREPARATION, CHARACTERIZATION AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF NNDMAC BIODEGRADABLE PARENTERAL SUSTAINED RELEASE MICROSPHERES
The objective of this work was to prepare biodegradable sustained release parenteral
microspheres of NNDMA-curcumin (NNDMAC), a novel curcumin analogue, characterize the
formulation and evaluate the hepatoprotective activity of the microsphere formulation.
Microspheres were prepared using solvent evaporation technique using polycaprolactone and
were further characterized for various parameters. In vivo animal studies for 10 days were carried
out for the determination of hepatoprotective activity of the formulation in a CCl4 model.
Particles of 12 μm size with 75.41% yield with no drug-polymer interaction were obtained. The
drug release was sustained for 10 days. Significant hepatoprotection which was better than
repeated I.V. administration was offered by the microsphere formulation in this 10-day study.
Prepared NNDMAC microspheres have potential use in liver toxicity/cirrhosis.
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