FORMULATION AND EVALUATION OF THE METHANOLIC EXTRACT OF CAESALPINIA PULCHERRIMA LEAVES FOR ITS WOUND HEALING ACTIVITY

KAVITH AN, NAIRA NAYEEM

Abstract


The present study was aimed at formulating and evaluating the methanolic extract of the leaves of Caesalpinia pulcherrima for its wound healing activity. Excision and incision wound models were used for the evaluation of the activity .Healthy animals were divided into four groups and they were treated as follows: Group I: control, Group II: standard nitrofurazone 0.2% (w/w) ointment, Group III: ointment base and Group IV: formulation .The animals treated with the extract exhibited significant wound healing activity. The period of epithelization (100%) for the animals treated with the extract was 14 days when compared to the control group which was 20 days. This activity was attributed to the analgesic, antiinflammatory, anti bacterial and anti oxidant activities of the plant.

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