CACO-2 CELLS: AN OVERVIEW

LAKSHMANA RAO, SANKAR

Abstract


The Caco-2 cell line is an immortalized line of heterogeneous human epithelial
colorectal adenocarcinoma cells. Human colonic adenocarcinoma cells that are able to
express differentiation features characteristic of mature intestinal cells, such as
enterocytes or mucus cells. These cells are valuable in vitro tools for studies related to
intestinal cell function and differentiation. The Caco-2 cell line is widely used with in
vitro assays to predict the absorption rate of candidate drug compounds across the
intestinal epithelial cell barrier. Caco-2 may also refer to a cell monolayer absorption
model. Cell-based functional assays, such as the Caco-2 drug transport model for
assessing intestinal transport, are extremely valuable for screening lead compounds in
drug discovery


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