DEVELOPMENT AND VALIDATION OF ABSORBANCE CORRECTION METHOD FOR SIMULTANEOUS ESTIMATION OF ALISKIREN AND AMLODIPINE IN COMBINED DOSAGE FORM

PATEL SAMIXA RAMESHBHAI, PATEL CHHAGANBHAI NANJIBHAI

Abstract


The present paper describes simple, accurate, rapid, precise and sensitive UV spectrophotometric absorption
correction method for the simultaneous determination of amlodipine and aliskiren in combined tablet dosage form. methanol was
used as solvent. The wavelengths selected for the analysis using absorption correction method were 354.5 nm and 256.0 nm for
estimation of amlodipine and aliskiren respectively. Beer’s law obeyed in the concentration range of 10-60 μg/mL and 20-120
μg/mL for amlodipine and aliskiren, respectively. The mean percentage drug content for amlodipine and aliskiren were found to
be 99.9. ± 1.38 and 99.87 ± 1.25 respectively and the % RSD value was found to be less than 2 which shows the precision
of method. The high recovery and low coefficients of variation conforms the suitability for the routine quality control analysis of
amlodipine and aliskiren in pure and pharmaceutical dosage forms.


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