PREPARATION AND EVALUATION OF EXTENDED RELEASE NIMESULIDE TABLET BASED ON DIFFUSION CONTROLLED MECHANISM

VIVEK P. CHAVDA, VISHAL RUPAPARA MOINUDDIN M. SONIWALA, JAYANT R. CHAVDA

Abstract


Now a days the concept of controlled release is quiet popular amongst the formulation scientists. The aim of this
study was to develop a once-daily sustained release matrix tablet of Nimesulide using hydroxyl propyl
methylcellulose (HPMC K4M) as release controlling factor and to evaluate drug release parameters as per various
release kinetic models. The tablets were prepared using wet granulation method. Total of five batches were prepared
from which two selected batches were further evaluated. Different dissolution models were applied to drug release
data in order to evaluate release mechanisms and kinetics. The “n” Value of both batches indicates that the drug
release mechanism follows “Anomalous Transport”. From all these data it is quite clear that batch F2 is optimized as
its release kinetic was found to be as per Korsmeyer Peppas model rather than first order of F4.


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