COMPREHENSIVE REVIEW ON ETHANOBOTANICAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES OF MELIA AZEDARACH LINN.
Medicinal plants, since times immemorial, have been used in virtually all cultures for therapeutic purposes. The widespread use of herbal remedies and healthcare preparations obtained from commonly used traditional herbs and medicinal plants have been traced to the occurrence of natural products with medicinal properties. In the present review, an attempt has been made to collect the botanical, phytochemical, ethnomedicinal, pharmacological and toxicological information on Melia azedarach L. which is used traditionally as an anthelmintic, diuretic, emmenagouge, expectorant, vermifuge, used in piles, used as astringent, used in hysteria, leprosy, and in scrofula. Medicinally it has been shown to possess various pharmacological activities like antifungal, anti-malarial, antibacterial, hepatoprotective, anti-oxidant, anti-fertility, anthelmintic, antipyretic and cytotoxic activities. The available literature on the M. azedarach L. revealed that this plant contains many phytochemical constituents including alkaloids, terpenoids, saponins, glycosides, phenolic compounds, flavonoids and rutins. The aim of this article is to review those medicinal and pharmacological properties of M. azedarach which have been or still are being learned. The present review is therefore, an effort to give a detailed survey of the literature on its traditional, phytochemical and pharmacological properties.
Kumar R, Singh R, Meera RS, Kalidhar Sb. Chemical components and Insectisidal properties of Bakyain (Melia azedarach L.), A Review. Agric Rev 2003; 24: 101-115.
Rubae AY. The Potential Uses of Melia Azedarach L. as Pesticidal and Medicinal Plant, Review. American-Eurasian J Sus Agri 2009; 3:185-194.
Burks, KC. Melia azedarach. Fact sheet prepared by the Bureau of Aquatic Plant Management, Department of Environmental Protection, State of Florida, Tallahassee, FL.1992.
Sen A and Batra A. Chemical composition of methanol extract of the leaves of Melia azedarach. Asian J Pharma Clin Res 2012; 5: 42-45.
Carpinella MC, Ferrayolic CG, Palacios SM. Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Msynergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits. J Agric Food Chem 2005; 53: 2922-2927.
Kumar BP, Kannana MM, Lavanyaa B, Suthakaranb R, Quinec D S. GC-MS analysis of methanolic extract of Litsea decanensis gamble and its free radical scavenging activity. J of Pharma. Res 2011; 4: 100-103.
Han B, Zhou P, Cui L, Fu J. Characterization of the key aromatic constituents in tea flowers of elite Chinese tea cultivars. Orig Res Rep 2003; 21: 31-36.
Apers S, Preininger L, Gimelfarb H, Li C, Dias BE, Fahmy F, White JM, Paper D, Bürgermeister J, Baronikova S, Dyck VS, Lemiére G, Vlietinck A, Pieters L. Antiangiogenic Activity of Synthetic Dihydrobenzofuran Lignans. J Nat Prod 2002; 65: 718-720.
Duetz WA, Bouwmeester H, Beilen JB, Witholt B. Biotransformation of limonene by bacteria, fungi, yeasts, and plants. Appl Microbiol Biotechnol 2003; 61: 269–277.
Sidhaye RV, Dhanawade AE, Manasa K, Aishwarya G. Synthesis, antimicrobial and antimycobacterial activity of nicotinic acid hydrazide derivatives. Curr Pharma Res 2011; 1: 135-139.
Dhiman, AK. Sacred Plants and their Medicinal Uses. Daya publishing House, Delhi, 2003, p. 125-127.
Sharma, PC, Yelne, MB, Dennis,TJ. Data base on Medicinal plants used in Ayurveda, Documentation and Publication Division, Central Council for Research in Ayurveda and Siddha, New Delhi 2001, p. 389-406.
Warrier, PK, Nambiar, Ramankutty VPK, C. Indian medicinal plants, a compendium of 500 species, Orient Longman Limited, Hyderabad, 1995, p. 10-14.
Rani M, Suhag, P, Kumar, R, Singh, R, Kalidhar, SB. Chemical component and biological efficacy of Melia azedarach stems. J Med Aroma Plant Sci 1999; 21: 1043-1047.
Ahmed MF, Rao AS, Ahemad SR. and Ibrahim M. Phytochemical studies and antioxidant activity of Melia azedarach linn leaves by DPPH scavenging Assay, Int J Pharma Appl 2012; 3: 271-276.
Vishnukanta, AC, Rana AC. Antifertility activity of Melia azedarach linn. (Meliaceae) in female Wistar rats. Pharmacologyonline 2009; 2: 117-132.
Roop JK, PK, Dhaliwal and Guraya SS. Extracts of Azadirachta indica and Melia azedarach seeds inhibit folliculogenesis in albino rats. Plant extracts inhibit rat folliculogenesis. Brazilian J Med Biol Res 2005; 38: 943-947.
Munir A, Sultana B, Babar T, Bashir A, Amjad M and Hassan Q. Investigation on the Antioxidant Activity of Leaves, Fruit and Stem Bark of Dhraik (Melia azedarach). European J Appl Sci 2012; 4: 47-51.
Ahmed MF, Rao AS, Ahemad SR and Ibrahim M. Phytochemical Studies and Hepatoprotective activity of Melia azedarach Linn, against CCl4 induced Hepatotoxicity in rats. J Pharm Res 2012; 5: 2664-2667.
Sultana S, Akhtar N, Asif HM. Phytochemical screening and Antipyretic effects of Hydromethanol extract of Melia azedarach leaves in rabbits. Bangladesh J Pharmacol 2013; 8: 214-217.
Jafari S, Saeidnia S, Hajimehdipoor H, Ardekani SMR, Faramarzi MA, Hadjiakhoond A. and Khanavi M. Cytotoxic evaluation of Melia azedarach in comparison with, Azadirachta indica and its phytochemical investigation. DARU J Pharma Sci 2013; 1:21-37.
Saleem, R, Ahmed SI, Faizi S, Siddiqui. Antibacterial effect of Melia azedarach on rabbits. Phytother Res 2002; 16: 762-4.
Saleem, R, Rani R, Ahmed M, Sadaf F, Ahmad SI, Zafar N, Khan SS, Siddiqui BS, Lubna, F, Ansari SA, Khan and Faizi S. Effect of a cream containing Melia azedarach flowers on skin diseases in children. Phytomed 2008; 15:231-236.
Wachsman, MB, V, Castilla, Coto C. Inhibition of foot and mouth disease virus (FMDV) uncoating by plant - derived peptide isolated from Melia azedarach L. Leaves. Arch. Virod 1998; 143: 581-590.
Alche, LE, GA, Ferek M, Meo, CE, Coto, MS, and Maier. An antiviral meliacarpin from leaves of Melia azedarach L. Verlag der Zeitschrift fur Naturforschung Tubingen 2001; 58: 215-219.
Rhaymah MSH. Anticomplementary activities of aqueous extract of the fruit of Melia azedarach and Cotoneaster prostratae in rats. J Animal Vet Adv 2006; 5:197-199.
Khan AV, Ahmed QU, Mir MR, Shukla I, khan AA. Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains. Asian Pacific J Trop Biomed 2011; 1: 452-455.
Christina, AJM, Najumadeen NAH, Kumar SV, Mainikandan N, Tobin GC, Venkataraman S, Murugesh N. Antilithiatic effect of on Melia azedarach ethylene glycol-induced nephrolithiasis in rats. Pharma Biol 2006; 44: 480 - 485.
Lee BG, Kim SH, Zee OP, Lee KR, Lee HY, Hana JW, Lee WH. Suppression of inducible nitric oxide synthase expression in RAW 264.7macrophages by two b-carboline alkaloids extracted from Melia azedarach. European J Pharmacol 2000; 406: 301–309.
Charturvedi, Raseroka P, Ntshebe BH, O. Antimalarial activity of Melia azedarach. J App Zoolo Res 2006; 17: 109-113.
Moursi, SAH, IMH, AL-Khatib. Effect of Melia azedarach fruits on Gipsing - restraint stress-induced Ulcers in rats. Japan J Pharmacol 1984: 36: 527 - 533.
Lee, YS, IB, Chung, Choi WH, Cho YJ, Chu JP, BI, Min, EH Shin. Inhibitory effects of Melia azedarach L. extracts on the growth of Trichomonus vaginalis Ultrastructural changes of Trichomonu vaginalis by Melia azedarach L., J Protozool. Res 2007; 17: 16-24.
Szewezuk VD, Mongelli ER and Pomilio AB. Antiparasitic activity of Melia azedarach growing in Argentina, Mol Med chem 2003; 1: 5457.
Kayastha BP. Silvics of the trees of Nepal. Community Forest Development Project, Kathmandu 1985; 2:189-196.
Vidya V, Srinivasan, Sengottuvelu. Wound healing potential of Melia azedarach L. leaves in alloxan induced diabetic rats. Global J Res Med Plants & Indi Med 2012; 1: 265-271.
Rahman, Ahmad S, Qureshi S, Ranman AU, Badar Y. Toxicological studies of Melia azedarach (flowers and berries) Pak J Pharma Sci 1991; 4: 153-158.
- There are currently no refbacks.
Listed as Green Publisher