The Relationship between High Sensitive C-reaction Protein (hs-CRP) and Diastolic Heart Function in Diabetes Mellitus Type II
Among several inflammatory markers, high sensitive C-reaction protein (hs-CRP) is outstandingly observed in diabetic individuals. Serum hs-CRP is the main marker of inflammation whose levels independently predict the risk of cardiovascular events, and it has a prognostic value in heart patients. On the other hand, diabetes can lead to diastolic dysfunction of the heart. Diastolic dysfunction can cause symptoms of exertional dyspnea, which restricts the patient’s activity. It is likely to predict diastolic dysfunction by screening through hs-CRP. The present investigation was a case-control study that was carried out on 52 patient diagnosed with diabetes mellitus type II. After the demographic data were recorded, and following the collection of data on the patients’ history, physical examination, and para-clinical measures, individuals who had factors interfering with level of serum hs-CRP (kidney and liver diseases, inflammatory and infectious diseases, peripheral vascular disease, cerebrovascular disease, connective tissue disease, malignant tumor, trauma, consumption
of statins, aspirin, ACEI, and fibrates) and diastolic dysfunction (ischemic heart disease, cardiomyopathies, pericardial disease, arrhythmias and valvular disease) were crossed out of the study. Serum hs-CRP was measured by nephelometry method. According to the results of tissue Doppler echocardiography, these patients are divided into two groups: one
with diastolic dysfunction and the other without diastolic dysfunction. The serum hs-CRP levels of these patients were compared with each other. Among the participants, 30.8% were men and 69.2% were women, 36 individuals (69.2%) had diastolic dysfunction while 16 (30.8%) did not. There was a high level of correlation between the level of serumhs-CRP and diastolic dysfunction (p=0.02, t=2.36). The results of the present study indicated that there is a correlation between level of serum hs-CRP and diastolic dysfunction, such that the more the level of hs-CRP, the higher probability of diastolic dysfunction existence will be.
Harrison’s Principles of Internal Medicine. 17th ed.US: Mc-
Graw Hill Education. 2008. Part 15, Section One, Chapter
; Diabetes Mellitus 1463–70.
Shan, et al. Interleukin 18 and interleukin 18 binding protein
in patients with idiopathic thrombocytopenic purpura.
British J Haematology. 2009; 144(50):755–76.
Ridker PM, Rifai N, Clearfield M, et al. Measurement of
C-reactive protein for the targeting of statin therapy in the
primary prevention of acute coronary events.N Engl J Med.
Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison
of C-reactive protein and low-density lipoprotein
cholesterol levels in the prediction of first cardiovascular
events. N Engl J Med. 2002; 347:1557–65.
Danesh J, Wheeler JG, Hirschfield GM, et al. C–reactive
protein and other circulating, markers of inflammation
in the prediction of coronary heart disease. N Engl J Med.
Mahajan A, Tabassum R, Chavali S, Dwivedi OP, Bharadwaj
M, Tandon N, Bharadwaj D. High-sensitivity C-reactive
protein levels and type 2 diabetes in urban North Indians.J
Clin Endocrinol Metab. 2009 Jun; 94(6)2123–7.
Nagueh SF, Appleton CP, Gillbert TC, Marino PN, et al.
Recommendations for the evaluation of left ventricular diastolic
function by echocardiography. Joural of American
Society of Echocardiography. 2009; 22(2)103–33.
Otto CM. A textbook of clinical echocardiogaphy. 4th
ed.US: Elsevier Health. Chapter 7; p. 157–79.
Rajaram V, Evans AT, Caldito GC, Kelly RF, Fogelfeld L,
Black HR, Doukky R. High sensitivity C-reactive protein
is associated with diastolic dysfunction in young African
Americans without clinically evident cardiac disease:USA.
The Open Cardiovascular Medicine Journal. 2011; 5:188–
Michowitz Y, Arbel Y, Wexler D, Sheps D, Rogowski O,
Shapira I, Berliner S, Keren G, George J, Roth A. Predictive
value of high sensitivity CRP in patients with diastolic heart
failure. Int J Cardiol. 2008 Apr 25; 125(3)347–51.
Amanullah S, Jarari A, Govindan M , Basha MI, Khatheeja
S. Association of hs-CRP with diabetic and non-diabetic
individuals. Jordan Journal of Biological Sciences. 2010;
Yorulmaz E, Zunlulu MU, Alpaslan B, Oguz A. hs-CRP for
cardiovascular risk in diabetes: problems in daily practice.
Turkish Journal of Endocrinology and Metabolism. 2009;
- There are currently no refbacks.
Listed as Green Publisher