COMPUTATIONAL STUDIES OF SIRTUINS IN THE TREATMENT OF TYPE II DIABETES MELLITUS

Abstract

Ageing in humans refers to a biological process of life engaged with physical, psychological, and social changes. Different species of animals age at radically different paces and occurrences of diseases. Drug designing approaches related to an aging factor, Type 2 Diabetes mellitus has been reported in the present study. Resveratrol and human Sirtuins (1 to 6) are docked against Type 2 Diabetes mellitus HNF-1a motif with PDB ID: 2GYP using Hex 5.1. Resveratrol and Sirtuin 6 shown good results and can use as anti-aging drugs against Type 2 Diabetes mellitus.