STUDIES ON THE PREPARATION, CHARACTERIZATION AND SOLUBILITY OF Β-CYCLODEXTRIN-NELFINAVIR INCLUSION COMPLEXES

HIREMATH SN, GODGE GR, KHARIA AA VAIDYA VR

Abstract


Nelfinavir is a poor water-soluble antiretroviral drug with relatively low bioavailability. The effect of β-cyclodextrin on the aqueous solubility and dissolution rate of nelfinavir was investigated. Phase solubility studies indicated that the solubility of nelfinavir was significantly enhanced by complexing it with β- cyclodextrin. It was classified as Bs type indicating the 1:2 stoichiometric inclusion complexes. The various solid complexes prepared by physical mixture, Kneading, coprecipitation & common solvent methods were characterized by DSC, X-RD & FT-IR. Dissolution study showed that the solubility and dissolution rate of nelfinavir was significantly improved by complexation with β-cyclodextrin.

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